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KMID : 0604520070330010017
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Journal of the Society of Cosmetic Scientists of Korea
2007 Volume.33 No. 1 p.17 ~ p.22
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Sedum sarmentosum Enhances Hyaluronan Synthesis in Transformed Human Keratinocytes and Increases Water Content in Human Skin
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Sim Gwan-Sub
Kim Jin-Hwa
Lee Dong-Hwan
Na Young
Lee Geun-Soo
Pyo Hyeong-Bae
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Abstract
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In this study, we investigated the effects of Sedum sarmentosum extract on the expression of hyaluronan synthase (HAS) genes and hyaluronan (HA) production in HaCaT keratinocytes. We also assessed water content (electrical capacitance) and transepidermal water loss (TEWL) in human skin after topical treatment with Sedum sarmentosum extract. Sedum sarmentosum extract increased expression of HAS-2 and HAS-3 genes in HaCaT cells, when assayed by real-time reverse-transcriptase polymerase chain reactions (RT-PCR). Sedum sarmentosum extract induced HA production in HaCaT cells, when determined by enzyme-linked immunosorbent assay (ELISA). Finally, treatment of Sedum sarmentosum extract on human skin increased the skin hydration and decreased TEWL when measured using Corneometer and Tewameter. Our study suggests that Sedum sarmentosum extract should be a very useful cosmetic ingredient, as a skin moisturizer.
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KEYWORD
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Sedum sarmentosum, hyaluronan, hyaluronan synthase, HaCaT kerationcytes, moisturizer
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